human DEFA4 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human DEFA4.
shAAV-206795
AAV-h-DEFA4-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human DEFA4 (defensin alpha 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DEF4; HNP-4; HP-4; HP4
Description (Vector)
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production.
Gene ID
1669
Gene Name (Vector)
defensin alpha 4
Gene Symbol
DEFA4
HGNC ID
HGNC:2763
ORF Size (aa)
294
RefSeq ID
NM_001925
RefSeq Synonyms
NM_001925, BC112091, BC106747, BC093959,
Species
human
UniGene ID
Hs.591391
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.