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human DAZ4 shRNA silencing AAV

Name 
AAV-h-DAZ4-shRNA
Cat No 
shAAV-206609
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human DAZ4.

shAAV-206609
AAV-h-DAZ4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human DAZ4 (deleted in azoospermia 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
pDP1680; pDP1681
Description (Vector)
DAZ4 is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. DAZ4 contains two copies of the 10.8 kb repeat. Alternatively spliced transcript variants encoding different isoforms have been described.
Gene ID
57135
Gene Name (Vector)
deleted in azoospermia 4
Gene Symbol
DAZ4
ORF Size (aa)
1173
ORF Size (bp)
1173 bp
RefSeq ID
NM_020420
RefSeq Synonyms
NM_020420, NM_001005375, BC047617, BC047480,
Species
human
UniGene ID
Hs.70936

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.