human DARC shRNA silencing AAV

Name
AAV-h-DARC-shRNA

Cat No
shAAV-206602

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ACKR1.

shAAV-206602

AAV-h-DARC-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ACKR1 (atypical chemokine receptor 1 (Duffy blood group)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CCBP1; CD234; DARC; Dfy; FY; GPD; GpFy; WBCQ1

Description (Vector)

DARC is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene.

Gene ID

2532

Gene Name (Vector)

atypical chemokine receptor 1 (Duffy blood group)

Gene Symbol

ACKR1

HGNC ID

HGNC:4035

ORF Size (aa)

1011

ORF Size (bp)

1011 bp

RefSeq ID

NM_002036

RefSeq Synonyms

NM_002036, NM_001122951, BC017817,

Species

human

UniGene ID

Hs.153381

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.