human CYTH4 shRNA silencing AAV

Name
AAV-h-CYTH4-shRNA

Cat No
shAAV-206549

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CYTH4.

shAAV-206549

AAV-h-CYTH4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CYTH4 (cytohesin 4). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CYT4; cytohesin-4; DJ63G5.1; PSCD4

Description (Vector)

CYTH4 is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with both ARF1 and ARF5 but is inactive with ARF6. The structures of this gene and CYTH1 are very similar.

Gene ID

27128

Gene Name (Vector)

cytohesin 4

Gene Symbol

CYTH4

HGNC ID

HGNC:9505

ORF Size (aa)

1185

ORF Size (bp)

1185 bp

RefSeq ID

NM_013385

RefSeq Synonyms

NM_013385, NM_001318024, BC041161, BC017780,

Species

human

UniGene ID

Hs.170944

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.