human CYP7B1 shRNA silencing AAV

Name
AAV-h-CYP7B1-shRNA

Cat No
shAAV-206531

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CYP7B1.

shAAV-206531

AAV-h-CYP7B1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CYP7B1 (cytochrome P450 family 7 subfamily B member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CBAS3; CP7B; SPG5A

Description (Vector)

CYP7B1 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis.

Gene ID

9420

Gene Name (Vector)

cytochrome P450 family 7 subfamily B member 1

Gene Symbol

CYP7B1

HGNC ID

HGNC:2652

ORF Size (aa)

1521

ORF Size (bp)

1521 bp

RefSeq ID

NM_004820

RefSeq Synonyms

NM_004820, NM_001324112, BC136574,

Species

human

UniGene ID

Hs.667720

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.