human CYP11B1 shRNA silencing AAV

Name
AAV-h-CYP11B1-shRNA

Cat No
shAAV-206444

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CYP11B1.

shAAV-206444

AAV-h-CYP11B1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CYP11B1 (cytochrome P450 family 11 subfamily B member 1). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CPN1; CYP11B; FHI; P450C11

Description (Vector)

CYP11B1 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene.

Gene ID

1584

Gene Name (Vector)

cytochrome P450 family 11 subfamily B member 1

Gene Symbol

CYP11B1

HGNC ID

HGNC:2591

ORF Size (aa)

1314

ORF Size (bp)

1314 bp

RefSeq ID

NM_000497

RefSeq Synonyms

NM_001026213, NM_000497, BC096287, BC096286, BC096285,

Species

human

UniGene ID

Hs.184927

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.