human CXCR3 shRNA silencing AAV

Name
AAV-h-CXCR3-shRNA

Cat No
shAAV-206343

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CXCR3.

shAAV-206343

AAV-h-CXCR3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CXCR3 (C-X-C motif chemokine receptor 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R; Mig-R; MigR

Description (Vector)

CXCR3 encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716).

Gene ID

2833

Gene Name (Vector)

C-X-C motif chemokine receptor 3

Gene Symbol

CXCR3

HGNC ID

HGNC:4540

ORF Size (aa)

1107

ORF Size (bp)

1107 bp

RefSeq ID

NM_001504

RefSeq Synonyms

NM_001504, NM_001142797, BC034403,

Species

human

UniGene ID

Hs.198252

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.