human CTLA4 shRNA silencing AAV

Name
AAV-h-CTLA4-shRNA

Cat No
shAAV-206235

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CTLA4.

shAAV-206235

AAV-h-CTLA4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CTLA4 (cytotoxic T-lymphocyte associated protein 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ALPS5;CD;CD antigen CD152;CD152;CD152 isoform;celiac disease 3;CELIAC3;CTLA-4;cytotoxic T lymphocyte associated antigen 4 short spliced form;cytotoxic T-lymphocyte protein 4;Cytotoxic T-lymphocyte-associated antigen 4;cytotoxic T-lymphocyte-associated serine esterase-4;GRD4;GSE;IDDM12;insulin-dependent diabetes mellitus 12;ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4

Description (eCommerce)

CTLA4 is a member of the immunoglobulin superfamily and is an inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P16410].

Description (Vector)

CTLA4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

Gene ID

1493

Gene Name (eCommerce)

cytotoxic T-lymphocyte associated protein 4

Gene Name (Vector)

cytotoxic T-lymphocyte associated protein 4

Gene Symbol

CTLA4

HGNC ID

HGNC:2505

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

672

ORF Size (bp)

672 bp

Protein Name (eCommerce)

Cytotoxic T-lymphocyte protein 4

RefSeq ID

NM_005214

RefSeq Synonyms

NM_005214, NM_001037631, BC074893, BC074842, BC070162, BC069566,

Research Areas

Apoptosis,B Cell Receptor Signaling,DNA Damage/Repair,Golgi Apparatus,Immunology,Signal Transduction,T Cell Receptor Signaling

Research Areas (Faceted)

cell_biology,genetics,transcription_translation,immunology,signal_transduction

Species

human

Target Sentence

UniGene ID

Hs.247824

UniProt ID (eCommerce)

P16410

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.