human CSTB shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CSTB.
shAAV-206189
AAV-h-CSTB-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CSTB (cystatin B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CPI-B; CST6; EPM1; EPM1A; PME; STFB; ULD
Description (Vector)
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1).
Gene ID
1476
Gene Name (Vector)
cystatin B
Gene Symbol
CSTB
HGNC ID
HGNC:2482
ORF Size (aa)
297
RefSeq ID
NM_000100
RefSeq Synonyms
NM_000100, BC010532, BC003370,
Species
human
UniGene ID
Hs.695
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.