human CSNK2A1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CSNK2A1.
shAAV-206149
AAV-h-CSNK2A1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CSNK2A1 (casein kinase 2 alpha 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
casein kinase 2, alpha 1 polypeptide; casein kinase II alpha 1 polypeptide pseudogene; casein kinase II alpha 1 subunit; casein kinase II subunit alpha; CK II alpha; CK2 catalytic subunit alpha; CK2A1; Cka1; Cka2; CKII; OCNDS; protein kinase CK2
Description (eCommerce)
Casein kinase II (CKII) is a serine/threonine protein kinase that is required for progression through the cell cycle but whose major functions are not clearly understood. CKII is composed of a heterotetrameric complex that includes alpha and alpha-prime catalytic subunits and a beta non-catalytic subunit. Although from independent genes, CKII alpha and CKII alpha-prime can compensate for each other for some functions. However in response to ionizing radiation (IR) damage, CKII alpha and CKII alpha-prime appear to function independently in inhibiting apoptosis signaling.
Description (Vector)
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene.
Gene ID
1457
Gene Name (eCommerce)
casein kinase 2 alpha 1
Gene Name (Vector)
casein kinase 2 alpha 1
Gene Symbol
CSNK2A1
HGNC ID
HGNC:2457
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1176
ORF Size (bp)
1176 bp
Protein Name (eCommerce)
Casein kinase II subunit alpha
RefSeq ID
NM_177559
RefSeq Synonyms
NM_177560, NM_177559, NM_001895, BC071167, BC053532, BC050036, BC011668,
Research Areas
Apoptosis,Axon Guidance,B-cell Receptor Signaling,BDNF Signaling,Cell Cycle,Host-Virus Interactions,IGF-1 Signaling,Immunology,Kinase/Phosphatase,Neurobiology,Neurodevelopment,NFAT Signaling,NF-kB Signaling,NGF Signaling,Notch Signaling,PDGF Signaling,Signal Transduction,TNF Signaling,TPO Signaling,Transcription Factor/Regulator,Wnt Signaling
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,transcription_translation,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
Casein kinase II (CKII) is a serine/threonine protein kinase that is required for progression through the cell cycle but whose major functions are not clearly understood. CKII is composed of a heterotetrameric complex that includes alpha and alpha-prime catalytic subunits and a beta non-catalytic subunit. Although from independent genes, CKII alpha and CKII alpha-prime can compensate for each other for some functions. However in response to ionizing radiation (IR) damage, CKII alpha and CKII alpha-prime appear to function independently in inhibiting apoptosis signaling.
UniGene ID
Hs.644056
UniProt ID (eCommerce)
P68400
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.