human CREB3 shRNA silencing AAV

Name
AAV-h-CREB3-shRNA

Cat No
shAAV-205973

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human CREB3.

shAAV-205973

AAV-h-CREB3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CREB3 (cAMP responsive element binding protein 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

LUMAN; LZIP; sLZIP

Description (Vector)

CREB3 encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.

Gene ID

10488

Gene Name (Vector)

cAMP responsive element binding protein 3

Gene Symbol

CREB3

HGNC ID

HGNC:2347

ORF Size (aa)

1116

ORF Size (bp)

1116 bp

RefSeq ID

NM_006368

RefSeq Synonyms

NM_006368, BC010158, BC009402,

Species

human

UniGene ID

Hs.522110

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.