human CPSF2 shRNA silencing AAV

Name 
AAV-h-CPSF2-shRNA
Cat No 
shAAV-205925
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CPSF2.

shAAV-205925
AAV-h-CPSF2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CPSF2 (cleavage and polyadenylation specific factor 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
cleavage and polyadenylation specific factor 2, 100kDa; cleavage and polyadenylation specificity factor 100 kDa subunit; cleavage and polyadenylation specificity factor subunit 2; CPSF 100 kDa subunit; CPSF 100kDa subunit; CPSF100
Description (eCommerce)
CPSF100/CPSF2 (cleavage and polyadenylation specific factor 2, 100 kDa subunit) is a subunit of the cleavage and polyadenylation specificity factor (CPSF) involved in mammalian mRNA 3’-end processing. CPSF, along with CstF (cleavage and stimulation factor), is critical for the recognition of cis-acting sequence elements on the pre-mRNA that dictate the site of cleavage and subsequent polyadenylation. CPSF exists as a complex of four proteins that includes CPSF160/CPSF1, CPSF100/CPSF2, CPSF73/CPSF3, and CPSF30/CPSF4. CPSF100/CPSF2 and CPSF73/CPSF3 are both members of the metallo-beta-lactamase superfamily of zinc-dependent hydrolases.
Gene ID
53981
Gene Name (eCommerce)
cleavage and polyadenylation specific factor 2
Gene Name (Vector)
cleavage and polyadenylation specific factor 2
Gene Symbol
CPSF2
HGNC ID
HGNC:2325
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2349
ORF Size (bp)
2349 bp
Protein Name (eCommerce)
Cleavage and polyadenylation specificity factor subunit 2
RefSeq ID
NM_017437
RefSeq Synonyms
NM_017437, NM_001322272, NM_001322271, NM_001322270, BC070095,
Research Areas
Gene Expression,mRNA Processing,mRNA Splicing,mRNA Transport,RNA Binding,RNA Processing,RNA Transport,Spliceosome
Research Areas (Faceted)
genetics,transcription_translation,cell_biology
Species
human
Target Sentence
CPSF100/CPSF2 (cleavage and polyadenylation specific factor 2, 100 kDa subunit) is a subunit of the cleavage and polyadenylation specificity factor (CPSF) involved in mammalian mRNA 3’-end processing. CPSF, along with CstF (cleavage and stimulation factor), is critical for the recognition of cis-acting sequence elements on the pre-mRNA that dictate the site of cleavage and subsequent polyadenylation. CPSF exists as a complex of four proteins that includes CPSF160/CPSF1, CPSF100/CPSF2, CPSF73/CPSF3, and CPSF30/CPSF4. CPSF100/CPSF2 and CPSF73/CPSF3 are both members of the metallo-beta-lactamase superfamily of zinc-dependent hydrolases.
UniGene ID
Hs.657632
UniProt ID (eCommerce)
Q9P2I0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.