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human CPSF1 shRNA silencing AAV

Name 
AAV-h-CPSF1-shRNA
Cat No 
shAAV-205924
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CPSF1.

shAAV-205924
AAV-h-CPSF1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CPSF1 (cleavage and polyadenylation specific factor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
cleavage and polyadenylation specific factor 1, 160kDa; cleavage and polyadenylation specificity factor 160 kDa subunit; cleavage and polyadenylation specificity factor subunit 1; CPSF 160 kDa subunit; CPSF160; HSU37012; P/cl.18; polyadenylation specificity factor
Description (eCommerce)
CPSF160/CPSF1 (cleavage and polyadenylation specific factor 1, 160 kDa subunit) is a subunit of the cleavage and polyadenylation specificity factor (CPSF) involved in mammalian mRNA 3’-end processing. CPSF, along with CstF (cleavage and stimulation factor), is critical for the recognition of cis-acting sequence elements on the pre-mRNA that dictate the site of cleavage and subsequent polyadenylation. CPSF exists as a complex of four proteins that includes CPSF160, CPSF100, CPSF73, and CPSF30. CPSF160 is responsible for recognizing the (AAUAAA) poly (A) signal for cleavage and polyadenylation.
Description (Vector)
Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 (PubMed 7590244)).(supplied by OMIM, Mar 2008)
Gene ID
29894
Gene Name (eCommerce)
cleavage and polyadenylation specific factor 1
Gene Name (Vector)
cleavage and polyadenylation specific factor 1
Gene Symbol
CPSF1
HGNC ID
HGNC:2324
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4332
ORF Size (bp)
4332 bp
Protein Name (eCommerce)
Cleavage and polyadenylation specificity factor subunit 1
RefSeq ID
NM_013291
RefSeq Synonyms
NM_013291, BC017232,
Research Areas
Gene Expression,mRNA Binding,mRNA Processing,mRNA Splicing,mRNA Transport,RNA Binding,RNA Processing,RNA Transport,Spliceosome
Research Areas (Faceted)
genetics,transcription_translation,cell_biology
Species
human
Target Sentence
CPSF160/CPSF1 (cleavage and polyadenylation specific factor 1, 160 kDa subunit) is a subunit of the cleavage and polyadenylation specificity factor (CPSF) involved in mammalian mRNA 3’-end processing. CPSF, along with CstF (cleavage and stimulation factor), is critical for the recognition of cis-acting sequence elements on the pre-mRNA that dictate the site of cleavage and subsequent polyadenylation. CPSF exists as a complex of four proteins that includes CPSF160, CPSF100, CPSF73, and CPSF30. CPSF160 is responsible for recognizing the (AAUAAA) poly (A) signal for cleavage and polyadenylation.
UniGene ID
Hs.493202
UniProt ID (eCommerce)
Q10570

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.