human CPB2 shRNA silencing AAV

Name
AAV-h-CPB2-shRNA

Cat No
shAAV-205878

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CPB2.

shAAV-205878

AAV-h-CPB2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CPB2 (carboxypeptidase B2 (plasma)). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CPU; PCPB; TAFI;

Description (Vector)

Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region.

Gene ID

1361

Gene Name (Vector)

carboxypeptidase B2 (plasma)

Gene Symbol

CPB2

HGNC ID

HGNC:2300

ORF Size (aa)

1272

ORF Size (bp)

1272 bp

RefSeq ID

NM_001872

RefSeq Synonyms

NM_016413, NM_001872, NM_001278541, BC007057,

Species

human

UniGene ID

Hs.512937

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.