human COPS5 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human COPS5.
shAAV-205770
AAV-h-COPS5-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human COPS5 (COP9 signalosome subunit 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
38 kDa Mov34 homolog; COP9 constitutive photomorphogenic homolog subunit 5; COP9 signalosome complex subunit 5; CSN5; JAB1; jun activation domain-binding protein 1; MOV-34; SGN5; signalosome subunit 5; testis secretory sperm-binding protein Li 231m
Description (eCommerce)
CSN5 is one of eight subunits (CSN1 to 8) of the highly conserved COP9 signalsome (CSN) complex originally identified as a regulator of light-mediated development in Arabidopsis. Characterization of CSN from yeast to mammals reveals its function as a modulator of signal transduction pathways involved in a variety of cellular and developmental processes. One of the major functions of the CSN is the regulation of protein degradation via intersection with the ubiquitin-proteasome pathway and regulation of E3-ubiquitin ligases. CSN also possesses kinase activity. CSN5 has been identified as the subunit that functions to remove Nedd8, an ubiquitin-like modifier, from cullin-based E3-ubiquitin ligases. CSN5 also functions as a coactivator of nuclear receptors. COP9 signalsome complex subunit 5, signalsome subunit 5, SGN5, jun activation domain-protein 1, COPS5, JAB1, MOV-34, MGC3149.
Description (Vector)
COPS5 is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.
Gene ID
10987
Gene Name (eCommerce)
COP9 signalosome subunit 5
Gene Name (Vector)
COP9 signalosome subunit 5
Gene Symbol
COPS5
HGNC ID
HGNC:2240
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1005
ORF Size (bp)
1005 bp
Protein Name (eCommerce)
COP9 signalosome complex subunit 5
RefSeq ID
NM_006837
RefSeq Synonyms
NM_006837, BC007272, BC001859, BC001187,
Research Areas
Cell Cycle,Hypoxia,JNK Signaling,Neurobiology,Nuclear Receptor Coactivators,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator,Translational Control,Ubiquitination
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,immunology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
CSN5 is one of eight subunits (CSN1 to 8) of the highly conserved COP9 signalsome (CSN) complex originally identified as a regulator of light-mediated development in Arabidopsis. Characterization of CSN from yeast to mammals reveals its function as a modulator of signal transduction pathways involved in a variety of cellular and developmental processes. One of the major functions of the CSN is the regulation of protein degradation via intersection with the ubiquitin-proteasome pathway and regulation of E3-ubiquitin ligases. CSN also possesses kinase activity. CSN5 has been identified as the subunit that functions to remove Nedd8, an ubiquitin-like modifier, from cullin-based E3-ubiquitin ligases. CSN5 also functions as a coactivator of nuclear receptors. COP9 signalsome complex subunit 5, signalsome subunit 5, SGN5, jun activation domain-protein 1, COPS5, JAB1, MOV-34, MGC3149.
UniGene ID
Hs.491912
UniProt ID (eCommerce)
Q92905
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.