human COL25A1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human COL25A1.
shAAV-205701
AAV-h-COL25A1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human COL25A1 (collagen type XXV alpha 1 chain). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AMY; CFEOM5; CLAC; CLAC-P; CLACP
Description (Vector)
COL25A1 encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
84570
Gene Name (Vector)
collagen type XXV alpha 1 chain
Gene Symbol
COL25A1
HGNC ID
HGNC:18603
ORF Size (aa)
1491
ORF Size (bp)
1491 bp
RefSeq ID
NM_032518
RefSeq Synonyms
NM_198721, NM_032518, NM_001256074, BC036669,
Species
human
UniGene ID
Hs.658842
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.