human COASY shRNA silencing AAV

Name 
AAV-h-COASY-shRNA
Cat No 
shAAV-205657
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human COASY.

shAAV-205657
AAV-h-COASY-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human COASY (Coenzyme A synthase). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
bifunctional coenzyme A synthase; bifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinase; CoA synthase; Dephospho-CoA kinase (DPCK); Dephospho-CoA pyrophosphorylase; Dephosphocoenzyme A kinase; DPCK; DPCOAK; NBIA6; NBP; nucleotide binding protein; Pantetheine-phosphate adenylyltransferase; Phosphopantetheine adenylyltransferase; phosphopantetheine adenylyltransferase / dephosphocoenzyme A kinase; pOV-2; PPAT; UKR1
Description (eCommerce)
Coenzyme A synthase (COASY) is a bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. COASY may act as a point of CoA biosynthesis regulation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13057].
Description (Vector)
Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. COASY is a bifunctional enzyme that catalyzes the 2 last steps in CoA synthesis. These activities are performed by 2 separate enzymes, phosphopantetheine adenylyltransferase (PPAT; EC 2.7.7.3) and dephospho-CoA kinase (DPCK; EC 2.7.1.24), in prokaryotes (Daugherty et al., 2002 (PubMed 11923312)).(supplied by OMIM, Mar 2008)
Gene ID
80347
Gene Name (eCommerce)
Coenzyme A synthase
Gene Name (Vector)
Coenzyme A synthase
Gene Symbol
COASY
HGNC ID
HGNC:29932
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1695
ORF Size (bp)
1695 bp
Protein Name (eCommerce)
Bifunctional coenzyme A synthase
RefSeq ID
NM_025233
RefSeq Synonyms
NM_025233, NM_001042532, NM_001042531, NM_001042530, NM_001042529, BC067254, BC020985, BC006354,
Research Areas
Metabolism/Metabolic Process
Research Areas (Faceted)
cell_biology,metabolism
Species
human
Target Sentence
Coenzyme A synthase (COASY) is a bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. COASY may act as a point of CoA biosynthesis regulation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13057].
UniGene ID
Hs.709231
UniProt ID (eCommerce)
Q13057

Recently Viewed Products

AAV-h-KIT-shRNA

Cat No: shAAV-213154

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.