human CNGA1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CNGA1.
shAAV-205569
AAV-h-CNGA1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CNGA1 (cyclic nucleotide gated channel alpha 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CNCG; CNCG1; CNG-1; CNG1; RCNC1; RCNCa; RCNCalpha; RP49
Description (Vector)
CNGA1 is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
1259
Gene Name (Vector)
cyclic nucleotide gated channel alpha 1
Gene Symbol
CNGA1
HGNC ID
HGNC:2148
ORF Size (aa)
2070
ORF Size (bp)
2070 bp
RefSeq ID
NM_000087
RefSeq Synonyms
NM_001142564, NM_000087, BC140399,
Species
human
UniGene ID
Hs.1323
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.