human CMBL shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CMBL.
shAAV-205540
AAV-h-CMBL-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CMBL (carboxymethylenebutenolidase homolog). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
JS-1
Description (Vector)
CMBL (EC 3.1.1.45) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an oxygen atom (Ishizuka et al., 2010 (PubMed 20177059)).(supplied by OMIM, Apr 2010)
Gene ID
134147
Gene Name (Vector)
carboxymethylenebutenolidase homolog
Gene Symbol
CMBL
HGNC ID
HGNC:25090
ORF Size (aa)
738
ORF Size (bp)
738 bp
RefSeq ID
NM_138809
RefSeq Synonyms
NM_138809, BC001573,
Species
human
UniGene ID
Hs.192586
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.