human CLNS1A shRNA silencing AAV

Name 
AAV-h-CLNS1A-shRNA
Cat No 
shAAV-205491
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CLNS1A.

shAAV-205491
AAV-h-CLNS1A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CLNS1A (chloride nucleotide-sensitive channel 1A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
chloride channel regulatory protein; chloride channel, nucleotide sensitive 1A; chloride conductance regulatory protein ICln; chloride ion current inducer protein; CLCI; CLNS1B; i(Cln); ICln; methylosome subunit pICln; reticulocyte pICln; reticulocyte protein ICln
Description (eCommerce)
Chloride channel nucleotide sensitive 1A (ICLN) is a protein that functions in multiple regulatory pathways. ICLN complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization.ICLN is also found associated with the plasma membrane where it functions as a chloride current regulator [taken from NCBI Entrez Gene (Gene ID: 1207)].
Description (Vector)
CLNS1A encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6.
Gene ID
1207
Gene Name (eCommerce)
chloride nucleotide-sensitive channel 1A
Gene Name (Vector)
chloride nucleotide-sensitive channel 1A
Gene Symbol
CLNS1A
HGNC ID
HGNC:2080
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
714
ORF Size (bp)
714 bp
Protein Name (eCommerce)
Methylosome subunit pICln
RefSeq ID
NM_001293
RefSeq Synonyms
NM_001311202, NM_001311201, NM_001311200, NM_001311199, NM_001293, BC119635, BC119634,
Research Areas
Cardiovascular,Cytoskeleton,Gene Expression,RNA Processing,RNA Transport,Spliceosome
Research Areas (Faceted)
cardiovascular,cell_biology,genetics,transcription_translation
Species
human
Target Sentence
Chloride channel nucleotide sensitive 1A (ICLN) is a protein that functions in multiple regulatory pathways. ICLN complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization.ICLN is also found associated with the plasma membrane where it functions as a chloride current regulator [taken from NCBI Entrez Gene (Gene ID: 1207)].
UniGene ID
Hs.598033
UniProt ID (eCommerce)
P54105

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.