human CLDN3 shRNA silencing AAV

Name
AAV-h-CLDN3-shRNA

Cat No
shAAV-205382

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CLDN3.

shAAV-205382

AAV-h-CLDN3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CLDN3 (claudin 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

C7orf1; CPE-R2; CPETR2; HRVP1; RVP1

Description (Vector)

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat.

Gene ID

1365

Gene Name (Vector)

claudin 3

Gene Symbol

CLDN3

HGNC ID

HGNC:2045

ORF Size (aa)

663

RefSeq ID

NM_001306

RefSeq Synonyms

NM_001306, BC016056,

Species

human

UniGene ID

Hs.647023

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.