human CIT shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CIT.
shAAV-205298
AAV-h-CIT-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CIT (citron rho-interacting serine/threonine kinase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CITK; citron (rho-interacting, serine/threonine kinase 21); citron Rho-interacting kinase; CRIK; MCPH17; serine/threonine kinase 21; serine/threonine-protein kinase 21; STK21
Description (eCommerce)
Citron is a dual specificity serine/threonine protein kinase and a putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It is required for KIF14 localization to the central spindle and midbody and may play a role in cytokinesis. Citron also plays an important role in the regulation of cytokinesis and the development of the central nervous system [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O14578].
Description (Vector)
CIT encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants.
Gene ID
11113
Gene Name (eCommerce)
citron rho-interacting serine/threonine kinase
Gene Name (Vector)
citron rho-interacting serine/threonine kinase
Gene Symbol
CIT
HGNC ID
HGNC:1985
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
6081
ORF Size (bp)
6081 bp
Protein Name (eCommerce)
Citron Rho-interacting kinase
RefSeq ID
NM_007174
RefSeq Synonyms
NM_007174, NM_001206999, BC172522, BC156529,
Research Areas
Cell Cycle,Cell Division,Cytoskeleton,Kinase/Phosphatase,Neurobiology,Neurodevelopment,Neurogenesis,Rho Signaling,Signal Transduction,Spermatogenesis,Zinc-finger
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,neurobiology,signal_transduction
Species
human
Target Sentence
Citron is a dual specificity serine/threonine protein kinase and a putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It is required for KIF14 localization to the central spindle and midbody and may play a role in cytokinesis. Citron also plays an important role in the regulation of cytokinesis and the development of the central nervous system [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O14578].
UniGene ID
Hs.119594
UniProt ID (eCommerce)
O14578
Recently Viewed Products
Ad-CMV-Luc
Cat No: 1000
Ad-CMV-Akt1 (Myr)
Cat No: 1020
Ad-CMV-Akt1 (dn)
Cat No: 1021
Ad-CMV-Akt1 (wt)
Cat No: 1022
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.