human CHMP5 shRNA silencing AAV

Name
AAV-h-CHMP5-shRNA

Cat No
shAAV-205168

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CHMP5.

shAAV-205168

AAV-h-CHMP5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CHMP5 (charged multivesicular body protein 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

C9orf83; CGI-34; HSPC177; PNAS-2; SNF7DC2; Vps60

Description (Vector)

CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 (PubMed 16730941)).(supplied by OMIM, Mar 2008)

Gene ID

51510

Gene Name (Vector)

charged multivesicular body protein 5

Gene Symbol

CHMP5

HGNC ID

HGNC:26942

ORF Size (aa)

660

ORF Size (bp)

660 bp

RefSeq ID

NM_016410

RefSeq Synonyms

NM_016410, NM_001195536, BC021168, BC020796, BC016698, BC007457, BC006974,

Species

human

UniGene ID

Hs.635313

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.