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human CHD6 shRNA silencing AAV

Name 
AAV-h-CHD6-shRNA
Cat No 
shAAV-205117
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CHD6.

shAAV-205117
AAV-h-CHD6-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CHD6 (chromodomain helicase DNA binding protein 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
50
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ATP-dependent helicase CHD6; CHD5; CHD-6; chromodomain-helicase-DNA-binding protein 6; helicase C-terminal domain- and SNF2 N-terminal domain-containing protein; radiation-induced gene B protein; RIGB
Description (eCommerce)
CHD6 is a member of the CHD (chromodomain-helicase-DNA-binding) family of proteins that interacts with nucleosomes and plays a role in chromatin remodeling to modulate transcription. The members of the CHD family of proteins possess 3 common structural and functional domains: a chromodomain (chromatin organization modifier), an SNF2-like helicase/ATPase domain, and a C-terminal DNA-binding domain. CHD6 has been shown to localize to sites of mRNA synthesis and associate with RNA polymerase II suggesting a role in RNA transcription and maturation.
Description (Vector)
Chromosomal DNA of eukaryotic cells is compacted by nuclear proteins to form chromatin, an organized nucleoprotein structure that can inhibit gene expression. Several multisubunit protein complexes exist to remodel the chromatin to allow patterns of cell type-specific gene expression. The protein encoded by this gene is thought to be a core member of one or more of these complexes. The encoded protein, which is a member of the SNF2/RAD54 helicase family, contains two chromodomains, a helicase domain, and an ATPase domain.
Gene ID
84181
Gene Name (eCommerce)
chromodomain helicase DNA binding protein 6
Gene Name (Vector)
chromodomain helicase DNA binding protein 6
Gene Symbol
CHD6
HGNC ID
HGNC:19057
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
8148
ORF Size (bp)
8148 bp
Protein Name (eCommerce)
Chromodomain-helicase-DNA-binding protein 6
RefSeq ID
NM_032221
RefSeq Synonyms
NM_032221, BC172397,
Research Areas
Chromatin Remodeling,Helicase Activity,Neurobiology,Neurodevelopment,Transcription Factor/Regulator
Research Areas (Faceted)
transcription_translation,cell_biology,neurobiology,developmental_biology,genetics
Species
human
Target Sentence
CHD6 is a member of the CHD (chromodomain-helicase-DNA-binding) family of proteins that interacts with nucleosomes and plays a role in chromatin remodeling to modulate transcription. The members of the CHD family of proteins possess 3 common structural and functional domains: a chromodomain (chromatin organization modifier), an SNF2-like helicase/ATPase domain, and a C-terminal DNA-binding domain. CHD6 has been shown to localize to sites of mRNA synthesis and associate with RNA polymerase II suggesting a role in RNA transcription and maturation.
UniGene ID
Hs.371979
UniProt ID (eCommerce)
Q8TD26

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.