human CFP shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CFP.
shAAV-205057
AAV-h-CFP-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CFP (complement factor properdin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BFD; PFC; PFD; PROPERDIN
Description (Vector)
CFP encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Gene ID
5199
Gene Name (Vector)
complement factor properdin
Gene Symbol
CFP
HGNC ID
HGNC:8864
ORF Size (aa)
1410
ORF Size (bp)
1410 bp
RefSeq ID
NM_002621
RefSeq Synonyms
NM_002621, NM_001145252, BC015756,
Species
human
UniGene ID
Hs.53155
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.