human CFHR1 shRNA silencing AAV

Cat. No: shAAV-205045

Availability: 6-8 weeks

Name: AAV-h-CFHR1-shRNA

This is an AAV expressing shRNA for silencing of Human CFHR1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CFHR1
Gene Name: complement factor H related 1
Gene ID: 3078
Gene Synonyms: CFHL; CFHL1; CFHL1P; CFHR1P; FHR1; H36-1; H36-2; HFL1; HFL2
ORF Size: 993 bp
RefSeq#: NM_002113
Gene Description: CFHR1 encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome.
UniGene ID: Hs.575869
HGNC ID: HGNC:4888