human CEP57 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CEP57.
shAAV-204996
AAV-h-CEP57-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CEP57 (centrosomal protein 57). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
MVA2; PIG8; TSP57
Description (Vector)
CEP57 encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID
9702
Gene Name (Vector)
centrosomal protein 57
Gene Symbol
CEP57
HGNC ID
HGNC:30794
ORF Size (aa)
1503
ORF Size (bp)
1503 bp
RefSeq ID
NM_014679
RefSeq Synonyms
NM_014679, NM_001243777, NM_001243776, BC039711, BC001233,
Species
human
UniGene ID
Hs.101014
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.