human CDK9 shRNA silencing AAV

Name 
AAV-h-CDK9-shRNA
Cat No 
shAAV-204866
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CDK9.

shAAV-204866
AAV-h-CDK9-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CDK9 (cyclin dependent kinase 9). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
C-2k; CDC2L4; CDC2-related kinase; cell division cycle 2-like protein kinase 4; cell division protein kinase 9; CTK1; cyclin-dependent kinase 9; PITALRE; serine/threonine protein kinase PITALRE; Serine/threonine-protein kinase PITALRE; TAK; tat-associated kinase complex catalytic subunit
Description (eCommerce)
Cyclin-dependent kinase 9 (CDK9) is a member of the CDK family of kinases and a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. CDK9 forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K.
Description (Vector)
CDK9 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS.
Gene ID
1025
Gene Name (eCommerce)
cyclin dependent kinase 9
Gene Name (Vector)
cyclin dependent kinase 9
Gene Symbol
CDK9
HGNC ID
HGNC:1780
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1119
ORF Size (bp)
1119 bp
Protein Name (eCommerce)
Cyclin-dependent kinase 9
RefSeq ID
NM_001261
RefSeq Synonyms
NM_001261, BC001968,
Research Areas
Cancer,Cardiac Hypertrophy,Cardiology,Cardiovascular,Cell Cycle,DNA Damage/Repair,EPO Signaling,Gene Expression,Histone Modification,Host-Virus Interactions,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Replication,RNA Binding,Signal Transduction,TGF-beta Signaling,TNF Signaling,Transcription Factor/Regulator,Transcriptional Misregulation in Cancer,VEGF Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,genetics,transcription_translation,immunology,infectious_disease,signal_transduction
Species
human
Target Sentence
Cyclin-dependent kinase 9 (CDK9) is a member of the CDK family of kinases and a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. CDK9 forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K.
UniGene ID
Hs.706809
UniProt ID (eCommerce)
P50750

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.