human CDK5RAP2 shRNA silencing AAV

Name 
AAV-h-CDK5RAP2-shRNA
Cat No 
shAAV-204856
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CDK5RAP2.

shAAV-204856
AAV-h-CDK5RAP2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CDK5RAP2 (CDK5 regulatory subunit associated protein 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
C48; CDK5 activator-binding protein C48; CDK5 regulatory subunit-associated protein 2; centrosomal protein 215 kDa; Centrosome-associated protein 215; centrosomin; Cep215; MCPH3
Description (eCommerce)
Mutations in CDK5RAP2 (CDK5 regulatory subunit-associated protein 2) have been linked to microcephaly. CDK5RAP2 may be involved in centrosome directed production of microtubules and mitotic spindle formation during neural cell division. CDK5RAP2 associates with the activating subunit of Cdk5, p25NCK5A. Cdk5 is a brain specific cyclin-dependent kinase important to mammalian brain development.
Description (Vector)
Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. The encoded protein may also be a substrate of neuronal CDC2-like kinase. Multiple transcript variants exist for this gene, but the full-length nature of only two has been determined.
Gene ID
55755
Gene Name (eCommerce)
CDK5 regulatory subunit associated protein 2
Gene Name (Vector)
CDK5 regulatory subunit associated protein 2
Gene Symbol
CDK5RAP2
HGNC ID
HGNC:18672
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5679
ORF Size (bp)
5679 bp
Protein Name (eCommerce)
CDK5 regulatory subunit-associated protein 2
RefSeq ID
NM_018249
RefSeq Synonyms
NM_018249, NM_001272039, NM_001011649, BC146782, BC143762, BC136275,
Research Areas
Brain Development,Cell Cycle,Cytoskeleton,Golgi Apparatus,Neurobiology,Neurodevelopment,Neurogenesis,Replication,Transcription Factor/Regulator
Research Areas (Faceted)
neurobiology,developmental_biology,cell_biology,cell_cycle,neurobiology,developmental_biology,cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
Mutations in CDK5RAP2 (CDK5 regulatory subunit-associated protein 2) have been linked to microcephaly. CDK5RAP2 may be involved in centrosome directed production of microtubules and mitotic spindle formation during neural cell division. CDK5RAP2 associates with the activating subunit of Cdk5, p25NCK5A. Cdk5 is a brain specific cyclin-dependent kinase important to mammalian brain development.
UniGene ID
Hs.269560
UniProt ID (eCommerce)
Q96SN8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.