human CDK2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CDK2.
shAAV-204839
AAV-h-CDK2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CDK2 (cyclin dependent kinase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
cdc2-related protein kinase; CDKN2; cell division protein kinase 2; cyclin-dependent kinase 2; p33 protein kinase; p33(CDK2)
Description (eCommerce)
Cyclin-dependent kinase 2 (CDK2) is a member of the CDK family of protein kinases that regulate cell cycle progression. CDK2 associates with cyclin E or cyclin A to drive the cell cycle through G1- and S-phase. Substrates of CDK2 include pRb, p53, p27, E2F, Brca1, CDK7, B-Myb, PP1 alpha, RNA Pol II CTD, axin, p220 NPAT, ribonucleotide reductase M2, Myo-D, MARCKS, HsCdc6, and CP110.
Description (Vector)
CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported.
Gene ID
1017
Gene Name (eCommerce)
cyclin dependent kinase 2
Gene Name (Vector)
cyclin dependent kinase 2
Gene Symbol
CDK2
HGNC ID
HGNC:1771
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
897
ORF Size (bp)
897 bp
Protein Name (eCommerce)
Cyclin-dependent kinase 2
RefSeq ID
NM_052827
RefSeq Synonyms
NM_052827, NM_001798, NM_001290230, BC003065,
Research Areas
B-cell Receptor Signaling,Breast Cancer,Cancer,Cell Cycle,Cell Division,Cytoskeleton,DNA Damage/Repair,DNA Replication,EGFR Signaling,EPO Signaling,FoxO Signaling,Glioma,Histone Modification,Host-Virus Interactions,Immunology,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Lung Cancer,Meiosis,mTOR Signaling,Neurobiology,p53 Signaling,PI3K/Akt Signaling,Prostate Cancer,Replication,SCF-KIT Signaling,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator,TSH Signaling,VEGF Signaling,Viral Carcinogenesis
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,stem_cell_biology,transcription_translation
Species
human
Target Sentence
Cyclin-dependent kinase 2 (CDK2) is a member of the CDK family of protein kinases that regulate cell cycle progression. CDK2 associates with cyclin E or cyclin A to drive the cell cycle through G1- and S-phase. Substrates of CDK2 include pRb, p53, p27, E2F, Brca1, CDK7, B-Myb, PP1 alpha, RNA Pol II CTD, axin, p220 NPAT, ribonucleotide reductase M2, Myo-D, MARCKS, HsCdc6, and CP110.
UniGene ID
Hs.689624
UniProt ID (eCommerce)
P24941
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.