human CDH8 shRNA silencing AAV

Name
AAV-h-CDH8-shRNA

Cat No
shAAV-204833

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CDH8.

shAAV-204833

AAV-h-CDH8-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CDH8 (cadherin 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Nbla04261

Description (Vector)

CDH8 encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance.

Gene ID

1006

Gene Name (Vector)

cadherin 8

Gene Symbol

CDH8

HGNC ID

HGNC:1767

ORF Size (aa)

2400

ORF Size (bp)

2400 bp

RefSeq ID

NM_001796

RefSeq Synonyms

NM_001796, BC113416,

Species

human

UniGene ID

Hs.368322

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.