human CDH2 shRNA silencing AAV

Name
AAV-h-CDH2-shRNA

Cat No
shAAV-204814

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human CDH2.

shAAV-204814

AAV-h-CDH2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CDH2 (cadherin 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

90

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

cadherin 2, type 1, N-cadherin (neuronal); cadherin-2; calcium-dependent adhesion protein, neuronal; CD antigen CD325; CD325; CDHN; CDw325; NCAD; N-cadherin; N-cadherin 1; neural cadherin

Description (eCommerce)

N-Cadherin, or Cadherin-2, is a classical cadherin and member of the cadherin superfamily. N-Cadherin is a calcium-dependent cell adhesion molecule that plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [taken from NCBI Entrez Gene (Gene ID: 1000)].

Description (Vector)

CDH2 is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.

Gene ID

1000

Gene Name (eCommerce)

cadherin 2

Gene Name (Vector)

cadherin 2

Gene Symbol

CDH2

HGNC ID

HGNC:1759

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2721

ORF Size (bp)

2721 bp

Protein Name (eCommerce)

Cadherin-2

RefSeq ID

NM_001792

RefSeq Synonyms

NM_001792, NM_001308176, BC036470,

Research Areas

Axonogenesis,BDNF Signaling,Cardiology,Cardiomyopathy,Cardiovascular,EGFR Signaling,FGF Signaling,MAPK Signaling,Neurobiology,Neurodevelopment,Rho Signaling,Signal Transduction,Translational Control,Wnt Signaling

Research Areas (Faceted)

cardiovascular,cell_biology,developmental_biology,neurobiology,signal_transduction,transcription_translation

Species

human

Target Sentence

N-Cadherin, or Cadherin-2, is a classical cadherin and member of the cadherin superfamily. N-Cadherin is a calcium-dependent cell adhesion molecule that plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [taken from NCBI Entrez Gene (Gene ID: 1000)].

UniGene ID

Hs.606106

UniProt ID (eCommerce)

P19022

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.