human CD53 shRNA silencing AAV

Name
AAV-h-CD53-shRNA

Cat No
shAAV-204665

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CD53.

shAAV-204665

AAV-h-CD53-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CD53 (CD53 molecule). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

MOX44; TSPAN25

Description (Vector)

CD53 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants encoding the same protein.

Gene ID

963

Gene Name (Vector)

CD53 molecule

Gene Symbol

CD53

HGNC ID

HGNC:1686

ORF Size (aa)

660

ORF Size (bp)

660 bp

RefSeq ID

NM_000560

RefSeq Synonyms

NM_001320638, NM_001040033, NM_000560, BC040693,

Species

human

UniGene ID

Hs.443057

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.