human CD27 shRNA silencing AAV

Name 
AAV-h-CD27-shRNA
Cat No 
shAAV-204617
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CD27.

shAAV-204617
AAV-h-CD27-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CD27 (CD27 molecule). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CD antigen CD27; CD27 antigen; CD27L receptor; S152; S152. LPFS2; T cell activation antigen S152; T14; T-cell activation antigen CD27; TNFRSF7; Tp55; Tumor necrosis factor receptor superfamily member 7; tumor necrosis factor receptor superfamily, member 7
Description (eCommerce)
CD27 is the receptor for CD70/CD27L. It may play a role in survival of activated T-cells.It may also play a role in apoptosis through association with SIVA1 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P26842].
Description (Vector)
CD27 is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
Gene ID
939
Gene Name (eCommerce)
CD27 molecule
Gene Name (Vector)
CD27 molecule
Gene Symbol
CD27
HGNC ID
HGNC:11922
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
783
ORF Size (bp)
783 bp
Protein Name (eCommerce)
CD27 antigen
RefSeq ID
NM_001242
RefSeq Synonyms
NM_001242, BC012160,
Research Areas
Apoptosis,Immunology,JNK Signaling,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology,immunology,signal_transduction
Species
human
Target Sentence
CD27 is the receptor for CD70/CD27L. It may play a role in survival of activated T-cells.It may also play a role in apoptosis through association with SIVA1 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P26842].
UniGene ID
Hs.355307
UniProt ID (eCommerce)
P26842

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.