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human CBX2 shRNA silencing AAV

Name 
AAV-h-CBX2-shRNA
Cat No 
shAAV-204197
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CBX2.

shAAV-204197
AAV-h-CBX2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CBX2 (chromobox 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CDCA6; cell division cycle associated 6; chromobox homolog 2 (Pc class homolog, Drosophila); chromobox protein homolog 2; M33; modifier 3; Pc class homolog; SRXY5
Description (eCommerce)
Chromobox protein homolog 2 is a component of the polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P19474].
Description (Vector)
CBX2 encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Gene ID
84733
Gene Name (eCommerce)
chromobox 2
Gene Name (Vector)
chromobox 2
Gene Symbol
CBX2
HGNC ID
HGNC:1552
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1599
ORF Size (bp)
1599 bp
Protein Name (eCommerce)
Chromobox protein homolog 2
RefSeq ID
NM_032647
RefSeq Synonyms
NM_032647, NM_005189, BC157074, BC156118,
Research Areas
Chromatin Remodeling,Complexome,Polycomb Proteins,Transcription Factor/Regulator
Research Areas (Faceted)
transcription_translation,cell_biology,genetics
Species
human
Target Sentence
Chromobox protein homolog 2 is a component of the polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P19474].
UniGene ID
Hs.368410
UniProt ID (eCommerce)
Q14781

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.