human CASR shRNA silencing AAV

Name
AAV-h-CASR-shRNA

Cat No
shAAV-204131

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CASR.

shAAV-204131

AAV-h-CASR-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CASR (calcium sensing receptor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CAR; EIG8; FHH; FIH; GPRC2A; HHC; HHC1; HYPOC1; NSHPT; PCAR1

Description (Vector)

CASR is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.

Gene ID

846

Gene Name (Vector)

calcium sensing receptor

Gene Symbol

CASR

HGNC ID

HGNC:1514

ORF Size (aa)

3237

ORF Size (bp)

3237 bp

RefSeq ID

NM_000388

RefSeq Synonyms

NM_001178065, NM_000388, BC112236, BC104999,

Species

human

UniGene ID

Hs.435615

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.