human CASP4 shRNA silencing AAV

Name 
AAV-h-CASP4-shRNA
Cat No 
shAAV-204117
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CASP4.

shAAV-204117
AAV-h-CASP4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CASP4 (caspase 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ICE(rel)II; ICEREL-II; ICH-2; Mih1; Mih1/TX; TX
Description (Vector)
CASP4 encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
Gene ID
837
Gene Name (Vector)
caspase 4
Gene Symbol
CASP4
HGNC ID
HGNC:1505
ORF Size (aa)
1134
ORF Size (bp)
1134 bp
RefSeq ID
NM_001225
RefSeq Synonyms
NM_033306, NM_001225, BC017839,
Species
human
UniGene ID
Hs.138378

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.