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human CASP2 shRNA silencing AAV

Name 
AAV-h-CASP2-shRNA
Cat No 
shAAV-204115
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CASP2.

shAAV-204115
AAV-h-CASP2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CASP2 (caspase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57
Description (Vector)
CASP2 encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene ID
835
Gene Name (Vector)
caspase 2
Gene Symbol
CASP2
HGNC ID
HGNC:1503
ORF Size (aa)
1359
ORF Size (bp)
1359 bp
RefSeq ID
NM_032982
RefSeq Synonyms
NM_032983, NM_032982, NM_001224, BC002427,
Species
human
UniGene ID
Hs.368982

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.