human CASP14 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CASP14.
shAAV-204112
AAV-h-CASP14-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CASP14 (caspase 14). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
CASP14 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.
Gene ID
23581
Gene Name (Vector)
caspase 14
Gene Symbol
CASP14
HGNC ID
HGNC:1502
ORF Size (aa)
729
ORF Size (bp)
729 bp
RefSeq ID
NM_012114
RefSeq Synonyms
NM_012114, BC103869, BC103868, BC069541,
Species
human
UniGene ID
Hs.466057
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.