human CARM1 shRNA silencing AAV

Name 
AAV-h-CARM1-shRNA
Cat No 
shAAV-204094
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CARM1.

shAAV-204094
AAV-h-CARM1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CARM1 (coactivator associated arginine methyltransferase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Coactivator-associated arginine methyltransferase 1; histone-arginine methyltransferase CARM1; PRMT4; protein arginine N-methyltransferase 4
Description (eCommerce)
Protein arginine methylation is a form of post-translational modification that is catalyzed by protein arginine methyltransferases (PRMTs). CARM1 (coactivator-associated arginine methyltransferase 1), also known as PRMT4, has been shown to interact with and methylate RNA splicing factors such as CA150 that link transcription to splicing. In this context, CARM1 may be involved in spinal muscular atrophy pathogenesis. CARM1 has also been found to be a coactivator of the NFKappaB transcription factor and the androgen receptor.
Description (Vector)
Protein arginine N-methyltransferases, such as CARM1, catalyze the transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine. Protein arginine methylation has been implicated in signal transduction, metabolism of nascent pre-RNA, and transcriptional activation (Frankel et al., 2002 (PubMed 11724789)).(supplied by OMIM, Mar 2008)
Gene ID
10498
Gene Name (eCommerce)
coactivator associated arginine methyltransferase 1
Gene Name (Vector)
coactivator associated arginine methyltransferase 1
Gene Symbol
CARM1
HGNC ID
HGNC:23393
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1824
ORF Size (bp)
1824 bp
Protein Name (eCommerce)
Histone-arginine methyltransferase CARM1
RefSeq ID
NM_199141
RefSeq Synonyms
NM_199141, BC172490, BC156435,
Research Areas
Cancer,Chromatin Remodeling,Estrogen Signaling,Histone Modification,Host-Virus Interactions,Metabolism/Metabolic Process,Methyltransferase,Neurobiology,Nuclear Receptor Coactivators,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,genetics,transcription_translation,infectious_disease,metabolism,neurobiology,signal_transduction
Species
human
Target Sentence
Protein arginine methylation is a form of post-translational modification that is catalyzed by protein arginine methyltransferases (PRMTs). CARM1 (coactivator-associated arginine methyltransferase 1), also known as PRMT4, has been shown to interact with and methylate RNA splicing factors such as CA150 that link transcription to splicing. In this context, CARM1 may be involved in spinal muscular atrophy pathogenesis. CARM1 has also been found to be a coactivator of the NFKappaB transcription factor and the androgen receptor.
UniGene ID
Hs.371416
UniProt ID (eCommerce)
Q86X55

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.