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human CARD11 shRNA silencing AAV

Name 
AAV-h-CARD11-shRNA
Cat No 
shAAV-204080
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CARD11.

shAAV-204080
AAV-h-CARD11-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CARD11 (caspase recruitment domain family member 11). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
bcl10-interacting maguk protein 3; BENTA; BIMP3; CARD-containing MAGUK protein 1; carma 1; CARMA1; caspase recruitment domain-containing protein 11; IMD11; IMD11A; PPBL
Description (eCommerce)
CARD-containing MAGUK protein 1 (CARMA1) belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). When expressed in cells, CARMA1 activates NF-kappaB and induces the phosphorylation of BCL10 [taken from NCBI Entrez Gene (GeneID: 84433)].
Description (Vector)
CARD11 belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.
Gene ID
84433
Gene Name (eCommerce)
caspase recruitment domain family member 11
Gene Name (Vector)
caspase recruitment domain family member 11
Gene Symbol
CARD11
HGNC ID
HGNC:16393
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3444
ORF Size (bp)
3444 bp
Protein Name (eCommerce)
Caspase recruitment domain-containing protein 11
RefSeq ID
NM_032415
RefSeq Synonyms
NM_032415, NM_001324281, BC111719,
Research Areas
Apoptosis,B-cell Receptor Signaling,Fc Receptor Signaling,Immunology,Innate Immunity,NF-kB Signaling,Signal Transduction,T-cell Receptor Signaling
Research Areas (Faceted)
signal_transduction,cell_biology,immunology,signal_transduction
Species
human
Target Sentence
CARD-containing MAGUK protein 1 (CARMA1) belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). When expressed in cells, CARMA1 activates NF-kappaB and induces the phosphorylation of BCL10 [taken from NCBI Entrez Gene (GeneID: 84433)].
UniGene ID
Hs.648101
UniProt ID (eCommerce)
Q9BXL7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.