human CAPN9 shRNA silencing AAV

Name
AAV-h-CAPN9-shRNA

Cat No
shAAV-204053

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CAPN9.

shAAV-204053

AAV-h-CAPN9-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CAPN9 (calpain 9). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

GC36; nCL-4

Description (Vector)

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

10753

Gene Name (Vector)

calpain 9

Gene Symbol

CAPN9

HGNC ID

HGNC:1486

ORF Size (aa)

1884

ORF Size (bp)

1884 bp

RefSeq ID

NM_006615

RefSeq Synonyms

NM_016452, NM_006615, NM_001319676, BC027993,

Species

human

UniGene ID

Hs.498021

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.