human CAPN6 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CAPN6.
shAAV-204050
AAV-h-CAPN6-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CAPN6 (calpain 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CalpM; CANPX; CAPNX; DJ914P14.1
Description (Vector)
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis.
Gene ID
827
Gene Name (Vector)
calpain 6
Gene Symbol
CAPN6
HGNC ID
HGNC:1483
ORF Size (aa)
1926
ORF Size (bp)
1926 bp
RefSeq ID
NM_014289
RefSeq Synonyms
NM_014289, BC000730,
Species
human
UniGene ID
Hs.496593
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.