human CALU shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CALU.
shAAV-203990
AAV-h-CALU-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CALU (calumenin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
calumenin; Crocalbin; crocalbin-like protein; IEF SSP 9302; multiple EF-hand protein
Description (eCommerce)
Calumenin is involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Calumenin seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O43852].
Description (Vector)
The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID
813
Gene Name (eCommerce)
calumenin
Gene Name (Vector)
calumenin
Gene Symbol
CALU
HGNC ID
HGNC:1458
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
948
Protein Name (eCommerce)
Calumenin
RefSeq ID
NM_001219
RefSeq Synonyms
NM_001219, NM_001199674, NM_001199673, NM_001199672, NM_001199671, NM_001130674, BC013383,
Research Areas
Golgi Apparatus,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology
Species
human
Target Sentence
Calumenin is involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Calumenin seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O43852].
UniGene ID
Hs.718425
UniProt ID (eCommerce)
O43852
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.