human C14ORF179 shRNA silencing AAV

Name
AAV-h-C14ORF179-shRNA

Cat No
shAAV-202658

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human IFT43.

shAAV-202658

AAV-h-C14ORF179-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human IFT43 (intraflagellar transport 43). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

C14orf179; CED3

Description (Vector)

IFT43 encodes a subunit of the intraflagellar transport complex A (IFT-A). IFT-A is a multiprotein complex that plays an important role in cilia assembly and maintenance by mediating retrograde ciliary transport. Mutations in this gene are a cause of cranioectodermal dysplasia-3 (CED3), also known as Sensenbrenner syndrome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene ID

112752

Gene Name (Vector)

intraflagellar transport 43

Gene Symbol

IFT43

HGNC ID

HGNC:29669

ORF Size (aa)

642

RefSeq ID

NM_052873

RefSeq Synonyms

NM_052873, NM_001255995, NM_001102564, BC010436,

Species

human

UniGene ID

Hs.532626

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.