human BMF shRNA silencing AAV

Name
AAV-h-BMF-shRNA

Cat No
shAAV-202176

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human BMF.

shAAV-202176

AAV-h-BMF-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human BMF (Bcl2 modifying factor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

BMF belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene ID

90427

Gene Name (Vector)

Bcl2 modifying factor

Gene Symbol

BMF

HGNC ID

HGNC:24132

ORF Size (aa)

555

ORF Size (bp)

555 bp

RefSeq ID

NM_033503

RefSeq Synonyms

NM_033503, NM_001003943, NM_001003942, NM_001003940, BC104985, BC104983, BC070043, BC069505, BC069328,

Species

human

UniGene ID

Hs.591104

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.