human BCS1L shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human BCS1L.
shAAV-202074
AAV-h-BCS1L-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human BCS1L (BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BCS; BCS1; BJS; FLNMS; GRACILE; h-BCS; h-BCS1; Hs.6719; MC3DN1; PTD
Description (Vector)
BCS1L encodes a homolog of the S. cerevisiae bcs1 protein which is involved in the assembly of complex III of the mitochondrial respiratory chain. The encoded protein does not contain a mitochondrial targeting sequence but experimental studies confirm that it is imported into mitochondria. Mutations in this gene are associated with mitochondrial complex III deficiency and the GRACILE syndrome. Five alternatively spliced transcripts encoding the same protein have been described.
Gene ID
617
Gene Name (Vector)
BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone
Gene Symbol
BCS1L
HGNC ID
HGNC:1020
ORF Size (aa)
1260
ORF Size (bp)
1260 bp
RefSeq ID
NM_004328
RefSeq Synonyms
NM_004328, NM_001320717, NM_001318836, NM_001257344, NM_001257343, NM_001257342, NM_001079866, BC007500, BC000416,
Species
human
UniGene ID
Hs.471401
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.