human BCLAF1 shRNA silencing AAV

Name 
AAV-h-BCLAF1-shRNA
Cat No 
shAAV-202068
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human BCLAF1.

shAAV-202068
AAV-h-BCLAF1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human BCLAF1 (BCL2 associated transcription factor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
bcl-2-associated transcription factor 1; BCLAF1 and THRAP3 family member 1; bK211L9.1; BTF
Description (eCommerce)
BTF is a transcriptional repressor that interacts with Bcl-2 related proteins to promote apoptosis. BTF has also been found to interact with emerin, a nuclear protein implicated in the muscle wasting disease Emery-Dreifuss muscular dystrophy.
Description (Vector)
BCLAF1 encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
9774
Gene Name (eCommerce)
BCL2 associated transcription factor 1
Gene Name (Vector)
BCL2 associated transcription factor 1
Gene Symbol
BCLAF1
HGNC ID
HGNC:16863
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2763
ORF Size (bp)
2763 bp
Protein Name (eCommerce)
Bcl-2-associated transcription factor 1
RefSeq ID
NM_001077440
RefSeq Synonyms
NM_014739, NM_001301038, NM_001077441, NM_001077440, BC144281, BC132780,
Research Areas
Apoptosis,DNA Damage/Repair,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
BTF is a transcriptional repressor that interacts with Bcl-2 related proteins to promote apoptosis. BTF has also been found to interact with emerin, a nuclear protein implicated in the muscle wasting disease Emery-Dreifuss muscular dystrophy.
UniGene ID
Hs.486542
UniProt ID (eCommerce)
Q9NYF8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.