human BCL10 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human BCL10.
shAAV-202033
AAV-h-BCL10-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human BCL10 (B-cell CLL/lymphoma 10). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
B-cell CLL/lymphoma 10; B-cell lymphoma/leukemia 10; Bcl-10; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; CARD-containing molecule enhancing NF-kappa-B; CARD-containing proapoptotic protein; CARD-like apoptotic protein; CARMEN; caspase-recruiting domain-containing protein; cCARMEN; c-E10; CED-3/ICH-1 prodomain homologous E10-like regulator; cellular homolog of vCARMEN; cellular-E10; CIPER; CLAP; hCLAP; IMD37; mammalian CARD-containing adapter molecule E10; mE10
Description (eCommerce)
B-cell lymphoma/leukemia 10 (Bcl10) promotes apoptosis, pro-caspase-9 maturation, and activation of NF-kappa-B via NIK and IKK. Bcl10 may be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Bcl10 Is a substrate for MALT1 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O95999].
Description (Vector)
BCL10 was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
Gene ID
8915
Gene Name (eCommerce)
B cell CLL/lymphoma 10
Gene Name (Vector)
B-cell CLL/lymphoma 10
Gene Symbol
BCL10
HGNC ID
HGNC:989
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
702
ORF Size (bp)
702 bp
Protein Name (eCommerce)
B-cell lymphoma/leukemia 10
RefSeq ID
NM_003921
RefSeq Synonyms
NM_003921, NM_001320715, BC053617,
Research Areas
Apoptosis,B-cell Receptor Signaling,Cancer,Fc Receptor Signaling,Immunology,Innate Immunity,Lysosome,Neurobiology,Neurodevelopment,NF-kB Signaling,Signal Transduction,T-cell Receptor Signaling,Toll-like Receptor Signaling,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,immunology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
B-cell lymphoma/leukemia 10 (Bcl10) promotes apoptosis, pro-caspase-9 maturation, and activation of NF-kappa-B via NIK and IKK. Bcl10 may be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Bcl10 Is a substrate for MALT1 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O95999].
UniGene ID
Hs.193516
UniProt ID (eCommerce)
O95999
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.