human BBOX1 shRNA silencing AAV

Name
AAV-h-BBOX1-shRNA

Cat No
shAAV-201992

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human BBOX1.

shAAV-201992

AAV-h-BBOX1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human BBOX1 (gamma-butyrobetaine hydroxylase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BBH; BBOX; G-BBH; gamma-BBH

Description (Vector)

BBOX1 encodes gamma butyrobetaine hydroxylase which catalyzes the formation of L-carnitine from gamma-butyrobetaine, the last step in the L-carnitine biosynthetic pathway. Carnitine is essential for the transport of activated fatty acids across the mitochondrial membrane during mitochondrial beta-oxidation.

Gene ID

8424

Gene Name (Vector)

gamma-butyrobetaine hydroxylase 1

Gene Symbol

BBOX1

HGNC ID

HGNC:964

ORF Size (aa)

1164

ORF Size (bp)

1164 bp

RefSeq ID

NM_003986

RefSeq Synonyms

NM_003986, BC011034,

Species

human

UniGene ID

Hs.591996

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.